modelPlasmaAcidBase
Information
plotExpression(apply(-log10(AlbuminTitration.H3O.solute)), false, "pH", 1);
The titration slope der(pH)/der(SID)=185 1/(mol/L) at pH=7.4 and tAlb=0.66 mmol/l.
Data and model is described in
Jame Figge: Role of non-volatile weak acids (albumin, phosphate and citrate). In: Stewart's Textbook of Acid-Base, 2nd Edition, John A. Kellum, Paul WG Elbers editors, AcidBase org, 2009, pp. 216-232.
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Integer | m | 4 | number of particle types in electroneutrality equation |
| Boolean[3] | isDependent | {false, false, false} | |
| Types.AmountOfSubstance | totalPO4 | 0.00115 | Total phosphate concentration |
| Types.AmountOfSubstance | totalAlb | 0.00066 | Total albumin concentration |
| Integer | n | 218 | Number of weak acid group in albumin molecule |
| Real[n] | pKAs | cat(1, {8.5}, fill(4.0, 98), fill(11.7, 18), fill(12.5, 24), fill(5.8, 2), fill(6.0, 2), {7.6, 7.8, 7.8, 8, 8}, fill(10.3, 50), {7.19, 7.29, 7.17, 7.56, 7.08, 7.38, 6.82, 6.43, 4.92, 5.83, 6.24, 6.8, 5.89, 5.2, 6.8, 5.5, 8, 3.1}) | acid dissociation constants |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Interfaces.ChemicalPort_a[3] | substances | {free dissolved CO2, bicarbonate, chloride} |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Components.Substance | H3O | hydrogen ions activity | |
| SteadyStates.Components.MolarConservationLaw[n] | tAlb | ||
| SteadyStates.Components.ElementaryChargeConservationLaw | electroneutrality | strong ion difference of solution | |
| Modelica.Blocks.Math.Gain | toColoumn | from elementary charge to to electric charge, which is needed in system | |
| Modelica.Blocks.Sources.ContinuousClock | SID_less_Cl | strong ions difference without chloride with respect to albumin charge shift | |
| Components.Substance[n] | A | deprotonated acid groups | |
| Components.ChemicalReaction[n] | react | ||
| Components.Substance[n] | HA | protonated acid groups | |
| Components.Substance | CO2_liquid | ||
| Components.Substance | HCO3 | ||
| Components.Substance | H2PO4 | ||
| Components.ChemicalReaction | phosphateAcidification | ||
| Components.Substance | HPO4 | ||
| SteadyStates.Components.MolarConservationLaw | tP04 | ||
| Components.Substance | Cl | chloride anion |
Revisions
2014
Marek Matejak, Charles University, Prague, Czech Republic