modelQuaternaryForm
Model of hemoglobin space-structure form (can be parametrized as relaxed or tensed)
Information
[1] Morrow J, Matthew J, Wittebort R, Gurd F. Carbon 13 resonances of 13CO2 carbamino adducts of alpha and beta chains in human adult hemoglobin. Journal of Biological Chemistry 1976;251:477-84.
[2] Bauer C, Schröder E. Carbamino compounds of haemoglobin in human adult and foetal blood. The Journal of physiology 1972;227:457-71.
[3] Antonini E, Wyman J, Brunori M, Fronticelli C, Bucci E, Rossi-Fanelli A. Studies on the relations between molecular and functional properties of hemoglobin V. The influence of temperature on the Bohr effect in human and in horse hemoglobin. Journal of Biological Chemistry 1965;240:1096-103.
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Boolean | isDependent | false | |
| Types.Concentration | KA | 10^(-6.89 + 3) | dissociation coefficient for acid chains of subunit |
| Types.Concentration | Kz | 10^(-7.25 + 3) | valine 1 amino terminus dissociation coefficient of protonation to NH3+ |
| Types.Concentration | Kc | 10^(-8.35 + 3) | valine 1 amino terminus dissociation coefficient of protonation to NH3+ |
| Types.Concentration | KO2 | 0.000671946 | oxygen dissociation coefficient of hemoglobin subunit |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Interfaces.ChemicalPort_a | O2 | ||
| Interfaces.ChemicalPort_a | sForm | ||
| Interfaces.ChemicalPort_a | H | hydrogen ion (proton) | |
| Interfaces.ChemicalPort_a | CO2 | ||
| Types.RealIO.AmountOfSubstanceOutput | tAmount | ||
| Types.RealIO.AmountOfSubstanceOutput | protonation | ||
| Types.RealIO.AmountOfSubstanceOutput | oxygenation |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Components.Speciation | Speciation | ||
| Components.Substance[4] | OxyHm | Oxygenated subunit of hemoglobin tetramer | |
| Components.ChemicalReaction[4] | oxygenation1 | ||
| Components.Substance[4] | DeoxyHm | Deoxygenated subunit of hemoglobin tetramer | |
| Modelica.Blocks.Math.Add[4] | add | ||
| Components.Substance[4] | A | residual acid chains of hemoglobin subunits | |
| Components.Substance[4] | HA | residual acid chains of hemoglobin subunits | |
| Components.ChemicalReaction[4] | protonation1 | ||
| Modelica.Blocks.Math.Add[4] | add1 | ||
| Components.Substance[4] | NH2 | Val1 terminal of hemoglobin subunits | |
| Components.Substance[4] | NH3 | Val1 terminal of hemoglobin subunits | |
| Components.ChemicalReaction[4] | protonation2 | ||
| Modelica.Blocks.Math.Add3[4] | add2 | ||
| Components.ChemicalReaction[4] | carboxylation | Carboxylation of Valin1 amino terminus of hemogloni subunit | |
| Components.Substance[4] | NHCOO | Val1 terminal of hemoglobin subunits | |
| Modelica.Blocks.Math.Sum | add3 | ||
| Modelica.Blocks.Math.Sum | add4 |
Revisions
2014
Marek Matejak, Charles University, Prague, Czech Republic