.Pharmacolibrary.DevModels.Remdesivir.ComponentRemdesivirPKPD

As Remdesivir bioavailability is almost 0 it is not fit for oral administration, thus intravenous administration is recommended first dose 200mg and other 4 - 10 doses per 100 mg every 24 h with intravenous application typically 30-60 minutes. 

RDV is taken by target cell and metabolized in multiple steps (utilizing enzymes hydrolaze, phosphataze) to form active form GS-443902. It is also metabolised (nucleotidase) to nonactive form GS-441524. 

Critical is concentration of active form in target cells.

RDV, active and non_active have different clearance rate elimination by kidneys/liver.

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