.Pharmacolibrary.Drugs.ATC.A.A01AB03

Information

name:Chlorhexidine
ATC code:A01AB03
route:oral
n-compartments1

Chlorhexidine is a broad-spectrum antiseptic and disinfectant used for skin disinfection before surgery and to sterilize surgical instruments. It is also used as a mouthwash to reduce oral bacteria and treat gingivitis. It is approved for topical and oral use in many countries, but is not intended for systemic administration.

Pharmacokinetics

Pharmacokinetic parameters reported in healthy adult volunteers after oral rinse and topical exposure. Systemic absorption is minimal due to poor gastrointestinal absorption and negligible percutaneous penetration.

References

  1. Toljanic, JA, et al., & Shapiro, RD (1992). Evaluation of the substantivity of a chlorhexidine oral rinse in irradiated head and neck cancer patients. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 50(10) 1055–1059. DOI:10.1016/0278-2391(92)90490-q PUBMED:https://pubmed.ncbi.nlm.nih.gov/1527659

  2. Lim, SY, et al., & Heard, CM (2020). Mucoadhesive thin films for the simultaneous delivery of microbicide and anti-inflammatory drugs in the treatment of periodontal diseases. International journal of pharmaceutics 573 118860–None. DOI:10.1016/j.ijpharm.2019.118860 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31759104

  3. Salmanli, M, et al., & Tuzuner, T (2021). Investigation of the antimicrobial activities of various antimicrobial agents on Streptococcus Mutans Sortase A through computer-aided drug design (CADD) approaches. Computer methods and programs in biomedicine 212 106454–None. DOI:10.1016/j.cmpb.2021.106454 PUBMED:https://pubmed.ncbi.nlm.nih.gov/34656905

Revisions


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