.Pharmacolibrary.Drugs.ATC.A.A01AC02

Information

Dexamethasone is a synthetic corticosteroid used for its anti-inflammatory and immunosuppressant effects. It is approved for use in a wide range of conditions including allergic disorders, skin diseases, rheumatic problems, certain cancers, and cerebral edema. It is also used in the management of COVID-19 in specific patient groups and remains a widely used and approved medication in clinical practice.

Pharmacokinetics

Pharmacokinetic parameters from healthy adult volunteers after single oral administration.

References

1. Wen, J, et al., & Gonzalez, D (2024). Pharmacokinetics of Dexamethasone in Children and Adolescents with Obesity. Journal of clinical pharmacology 64(12) 1491–1504. DOI:10.1002/jcph.6108 PUBMED:https://pubmed.ncbi.nlm.nih.gov/39120865

2. Wang, X, et al., & Kansra, V (2019). Population Pharmacokinetics of Rolapitant in Patients With Chemotherapy-Induced Nausea and Vomiting. Clinical pharmacology in drug development 8(7) 850–860. DOI:10.1002/cpdd.733 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31418538

3. Nakade, S, et al., & Miyata, Y (2008). Population pharmacokinetics of aprepitant and dexamethasone in the prevention of chemotherapy-induced nausea and vomiting. Cancer chemotherapy and pharmacology 63(1) 75–83. DOI:10.1007/s00280-008-0713-y PUBMED:https://pubmed.ncbi.nlm.nih.gov/18317761

Revisions

• 06/2025 initial generated model