.Pharmacolibrary.Drugs.ATC.A.A02AA04 .Pharmacolibrary.Drugs.ATC.A.A02AA04| name: | MagnesiumHydroxide |
| ATC code: | A02AA04 | route: | oral |
| n-compartments | 1 |
Magnesium hydroxide is an inorganic compound commonly used as an antacid to relieve indigestion, heartburn, and upset stomach, or as a saline laxative for short-term treatment of constipation. It acts by neutralizing stomach acid or by attracting water into the intestines. The drug is widely approved and available OTC in many countries.
Estimated pharmacokinetic parameters for oral administration in healthy adults; few data published due to very poor absorption from the gastrointestinal tract.
Scott, G, et al., & Rordorf, C (2004). Lack of effect of omeprazole or of an aluminium hydroxide/magnesium hydroxide antacid on the pharmacokinetics of lumiracoxib. Clinical pharmacokinetics 43(5) 341–348. DOI:10.2165/00003088-200443050-00006 PUBMED:https://pubmed.ncbi.nlm.nih.gov/15080766
Smith, GW, & Correa, MT (2004). The effects of oral magnesium hydroxide administration on rumen fluid in cattle. Journal of veterinary internal medicine 18(1) 109–112. DOI:10.1892/0891-6640(2004)18<109:teoomh>2.0.co;2 PUBMED:https://pubmed.ncbi.nlm.nih.gov/14765740
Zhang, YF, et al., & Zhong, DF (2014). Effects of an Al(3+)- and Mg(2+)-containing antacid, ferrous sulfate, and calcium carbonate on the absorption of nemonoxacin (TG-873870) in healthy Chinese volunteers. Acta pharmacologica Sinica 35(12) 1586–1592. DOI:10.1038/aps.2014.95 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25327812