.Pharmacolibrary.Drugs.ATC.A.A02BD11 .Pharmacolibrary.Drugs.ATC.A.A02BD11| name: | PantoprazoleAmoxicillinClarithromycinAndMetronidazole | |
| ATC code: | A02BD11 | route: | oral |
| compartments: | 1 | |
| dosage: | 2000 | mg |
| volume of distribution: | 18 | L |
| clearance: | 12 | L/h |
| other parameters in model implementation | ||
A fixed-combination regimen used in eradication of Helicobacter pylori infection. It contains pantoprazole (proton pump inhibitor), amoxicillin (penicillin-antibiotic), clarithromycin (macrolide-antibiotic), and metronidazole (nitroimidazole-antibiotic). These are combined to suppress gastric acid and provide broad-spectrum antibacterial action. The combination is used as first-line therapy in several clinical guidelines.
No experimental pharmacokinetic (PK) model for the fixed four-drug combination was identified; parameters herein are estimated based on representative oral PK profiles from literature for each drug in healthy adults.