.Pharmacolibrary.Drugs.ATC.A.A03BB03 .Pharmacolibrary.Drugs.ATC.A.A03BB03| name: | Methylscopolamine |
| ATC code: | A03BB03 | route: | oral |
| n-compartments | 1 |
Methylscopolamine is a quaternary ammonium derivative of scopolamine and acts as a muscarinic acetylcholine receptor antagonist. It is primarily used as an antispasmodic agent to relieve smooth muscle spasms in the gastrointestinal tract as well as to reduce salivation and other secretions. Due to its poor ability to cross the blood-brain barrier, it has fewer central nervous system effects than scopolamine. It is still available in some countries for gastrointestinal and other spasm-related disorders.
Estimated pharmacokinetic parameters for healthy adult oral administration. No published clinical pharmacokinetic studies with specific quantitative PK parameters for methylscopolamine found.
Yoshida, A, et al., & Yamada, S (2011). Characterization of muscarinic receptors in the human bladder mucosa: direct quantification of subtypes using 4-DAMP mustard. Urology 78(3) 721.e7–721.e12. DOI:10.1016/j.urology.2011.05.011 PUBMED:https://pubmed.ncbi.nlm.nih.gov/21777958
Ek, B, & Nahorski, S (1988). Muscarinic receptor coupling to inositol phospholipid metabolism in guinea-pig cerebral cortex, parotid gland and ileal smooth muscle. Biochemical pharmacology 37(23) 4461–4467. DOI:10.1016/0006-2952(88)90661-2 PUBMED:https://pubmed.ncbi.nlm.nih.gov/2849446