.Pharmacolibrary.Drugs.ATC.A.A03FA02 .Pharmacolibrary.Drugs.ATC.A.A03FA02| name: | Cisapride |
| ATC code: | A03FA02 | route: | oral |
| n-compartments | 2 |
Cisapride is a gastroprokinetic agent that was used primarily to treat gastroesophageal reflux disease (GERD) and other gastrointestinal motility disorders. It acts as a serotonin 5-HT4 receptor agonist, stimulating acetylcholine release at enteric neurons to enhance gut motility. Due to its ability to cause serious cardiac arrhythmias (QT prolongation, torsades de pointes), cisapride has been withdrawn or restricted in many countries and is no longer widely approved for use.
Pharmacokinetic parameters reported for healthy adult volunteers of both sexes receiving single oral doses of cisapride.
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