.Pharmacolibrary.Drugs.ATC.A.A04AA01 .Pharmacolibrary.Drugs.ATC.A.A04AA01| name: | Ondansetron |
| ATC code: | A04AA01 | route: | oral |
| n-compartments | 2 |
Ondansetron is a selective serotonin 5-HT3 receptor antagonist used primarily as an antiemetic to prevent nausea and vomiting caused by cancer chemotherapy, radiotherapy, and surgery. It is approved and widely used internationally.
Population pharmacokinetic parameters in healthy adult volunteers following single oral dose administration.
Zhu, Y, et al., & Zhu, J (2015). Pharmacokinetics and bioavailability study of two ondansetron oral soluble film formulations in fasting healthy male Chinese volunteers. Drug design, development and therapy 9 4621–4629. DOI:10.2147/DDDT.S86415 PUBMED:https://pubmed.ncbi.nlm.nih.gov/26316701
Fox-Geiman, MP, et al., & Stiff, P (2001). Double-blind comparative trial of oral ondansetron versus oral granisetron versus IV ondansetron in the prevention of nausea and vomiting associated with highly emetogenic preparative regimens prior to stem cell transplantation. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 7(11) 596–603. DOI:10.1053/bbmt.2001.v7.pm11760147 PUBMED:https://pubmed.ncbi.nlm.nih.gov/11760147
Zersen, KM, et al., & Shropshire, SB (2024). Plasma Concentrations of Oral Ondansetron in Hospitalized Dogs Exhibiting Clinical Signs of Nausea. Veterinary sciences 11(3) –. DOI:10.3390/vetsci11030112 PUBMED:https://pubmed.ncbi.nlm.nih.gov/38535846