name: | Ondansetron_1 |
ATC code: | A04AA01_1 | route: | intravenous |
n-compartments | 2 |
Ondansetron is a selective serotonin 5-HT3 receptor antagonist used primarily as an antiemetic to prevent nausea and vomiting caused by cancer chemotherapy, radiotherapy, and surgery. It is approved and widely used internationally.
Pharmacokinetic parameters following intravenous administration in healthy adults; parameters reflect standard IV dosing.
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Sotelo, CK, et al., & Zersen, KM (2022). Pharmacokinetics and anti-nausea effects of intravenous ondansetron in hospitalized dogs exhibiting clinical signs of nausea. Journal of veterinary pharmacology and therapeutics 45(6) 508–515. DOI:10.1111/jvp.13087 PUBMED:https://pubmed.ncbi.nlm.nih.gov/35899472
Chiang, MD, et al., & Haroutounian, S (2021). Plasma and cerebrospinal fluid pharmacokinetics of ondansetron in humans. British journal of clinical pharmacology 87(2) 516–526. DOI:10.1111/bcp.14412 PUBMED:https://pubmed.ncbi.nlm.nih.gov/32495990