.Pharmacolibrary.Drugs.ATC.A.A04AA01_1

Information

name:Ondansetron_1
ATC code:A04AA01_1
route:intravenous
n-compartments2

Ondansetron is a selective serotonin 5-HT3 receptor antagonist used primarily as an antiemetic to prevent nausea and vomiting caused by cancer chemotherapy, radiotherapy, and surgery. It is approved and widely used internationally.

Pharmacokinetics

Pharmacokinetic parameters following intravenous administration in healthy adults; parameters reflect standard IV dosing.

References

  1. Mondick, JT, et al., & Hoke, JF (2010). Population pharmacokinetics of intravenous ondansetron in oncology and surgical patients aged 1-48 months. European journal of clinical pharmacology 66(1) 77–86. DOI:10.1007/s00228-009-0730-8 PUBMED:https://pubmed.ncbi.nlm.nih.gov/19798490

  2. Sotelo, CK, et al., & Zersen, KM (2022). Pharmacokinetics and anti-nausea effects of intravenous ondansetron in hospitalized dogs exhibiting clinical signs of nausea. Journal of veterinary pharmacology and therapeutics 45(6) 508–515. DOI:10.1111/jvp.13087 PUBMED:https://pubmed.ncbi.nlm.nih.gov/35899472

  3. Chiang, MD, et al., & Haroutounian, S (2021). Plasma and cerebrospinal fluid pharmacokinetics of ondansetron in humans. British journal of clinical pharmacology 87(2) 516–526. DOI:10.1111/bcp.14412 PUBMED:https://pubmed.ncbi.nlm.nih.gov/32495990

Revisions


Generated at 2025-07-21T18:21:10Z by OpenModelicaOpenModelica 1.25.1 using GenerateDoc.mos