.Pharmacolibrary.Drugs.ATC.A.A04AA04_1 .Pharmacolibrary.Drugs.ATC.A.A04AA04_1| name: | Dolasetron_1 |
| ATC code: | A04AA04_1 | route: | oral |
| n-compartments | 2 |
Dolasetron is a selective serotonin 5-HT3 receptor antagonist used primarily as an antiemetic to prevent nausea and vomiting associated with chemotherapy, radiation, and surgery. It is currently approved for medical use in several countries.
Pharmacokinetic parameters reported in healthy adult volunteers after single oral administration.
Coppes, MJ, et al., & Pratt, CB (1999). Safety, tolerability, antiemetic efficacy, and pharmacokinetics of oral dolasetron mesylate in pediatric cancer patients receiving moderately to highly emetogenic chemotherapy. Journal of pediatric hematology/oncology 21(4) 274–283. DOI:10.1097/00043426-199907000-00007 PUBMED:https://pubmed.ncbi.nlm.nih.gov/10445889