.Pharmacolibrary.Drugs.ATC.A.A06AD18 .Pharmacolibrary.Drugs.ATC.A.A06AD18| name: | Sorbitol |
| ATC code: | A06AD18 | route: | oral |
| n-compartments | 1 |
Sorbitol is a sugar alcohol used as an osmotic laxative for the treatment of constipation and for bowel cleansing prior to medical procedures. It is also used in oral care products and as a sweetener in foods. Sorbitol is approved for use as a laxative in several countries.
Pharmacokinetic parameters for sorbitol are not well characterized in the literature due to its primary local action in the gut and minimal systemic absorption. Estimates below are provided based on typical osmotic laxative pharmacokinetics in healthy adults.
Yang, D, et al., & Chen, J (2024). Bioequivalence Study of Epalrestat for Healthy Chinese Subjects. Clinical pharmacology in drug development 13(5) 485–490. DOI:10.1002/cpdd.1347 PUBMED:https://pubmed.ncbi.nlm.nih.gov/37971280
Jain, NK, et al., & Pitchumoni, CS (1987). Sorbitol intolerance in adults. Prevalence and pathogenesis on two continents. Journal of clinical gastroenterology 9(3) 317–319. DOI:10.1097/00004836-198706000-00015 PUBMED:https://pubmed.ncbi.nlm.nih.gov/3611685
Matsui, K, et al., & Yokota, S (2021). Potential pharmacokinetic interaction between orally administered drug and osmotically active excipients in pediatric polypharmacy. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 165 105934–None. DOI:10.1016/j.ejps.2021.105934 PUBMED:https://pubmed.ncbi.nlm.nih.gov/34256099