.Pharmacolibrary.Drugs.ATC.A.A06AG04

Information

Glycerol (also known as glycerine or 1,2,3-propanetriol) is a simple polyol compound used medically as an osmotic laxative and to reduce intracranial and intraocular pressure. It is approved and widely used for its laxative effect, often administered rectally or orally.

Pharmacokinetics

Estimated pharmacokinetic parameters for healthy adults following oral administration, as no direct clinical PK studies were identified in the literature.

References

1. de Jonge, ME, et al., & Beijnen, JH (2005). Population pharmacokinetics of orally administered paclitaxel formulated in Cremophor EL. British journal of clinical pharmacology 59(3) 325–334. DOI:10.1111/j.1365-2125.2004.02325.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/15752379

2. Liu, X, et al., & Leggas, M (2019). Pharmacokinetic modeling of the blood-stable camptothecin analog AR-67 in two different formulations. Biopharmaceutics & drug disposition 40(8) 265–275. DOI:10.1002/bdd.2199 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31292985

3. Gietka-Czernel, M, et al., & Zgliczyński, W (2020). Expert opinion on liquid L-thyroxine usage in hypothyroid patients and new liquid thyroxine formulation - Tirosint SOL [Opinia ekspertów dotycząca stosowania płynnej postaci lewotyroksyny oraz nowego preparatu Tirosint SOL u chorych na niedoczynność tarczycy]. Endokrynologia Polska 71(5) 441–465. DOI:10.5603/EP.a2020.0065 PUBMED:https://pubmed.ncbi.nlm.nih.gov/33202031

Revisions

• 06/2025 initial generated model