.Pharmacolibrary.Drugs.ATC.A.A06AH03 .Pharmacolibrary.Drugs.ATC.A.A06AH03| name: | Naloxegol | |
| ATC code: | A06AH03 | route: | oral |
| compartments: | 2 | |
| dosage: | 25 | mg |
| volume of distribution: | 968 | L |
| clearance: | 168 | L/h |
| other parameters in model implementation | ||
Naloxegol is a peripherally acting mu-opioid receptor antagonist (PAMORA) used for the treatment of opioid-induced constipation (OIC) in adult patients with chronic non-cancer pain. It is approved for therapeutic use in multiple regions including the US and EU.
Pharmacokinetic parameters reported in healthy adult volunteers following single 25 mg oral dose during clinical studies.
Hruska, MW, et al., & Marsteller, DA (2024). Population Pharmacokinetics of Naloxegol in Pediatric Subjects Receiving Opioids. Clinical pharmacology in drug development 13(9) 974–984. DOI:10.1002/cpdd.1457 PUBMED:https://pubmed.ncbi.nlm.nih.gov/39110083
Eldon, MA, et al., & Sostek, M (2015). Safety, tolerability, and pharmacokinetics of multiple ascending doses of naloxegol. Clinical pharmacology in drug development 4(6) 442–448. DOI:10.1002/cpdd.204 PUBMED:https://pubmed.ncbi.nlm.nih.gov/27137716