.Pharmacolibrary.Drugs.ATC.A.A06AX06

Information

name:Tegaserod
ATC code:A06AX06
route:oral
n-compartments1

Tegaserod is a selective serotonin 5-HT4 receptor partial agonist used for the treatment of irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation in women under the age of 65. It was withdrawn from the market in many countries due to cardiovascular safety concerns but has since been reintroduced with restricted indication in some regions.

Pharmacokinetics

Pharmacokinetic parameters observed in healthy male and female adults following oral administration.

References

  1. Hamatani, T, et al., & Fujio, Y (2020). Thorough QT/QTc Study Shows That a Novel 5-HT. Clinical pharmacology in drug development 9(8) 938–951. DOI:10.1002/cpdd.778 PUBMED:https://pubmed.ncbi.nlm.nih.gov/32087003

  2. Appel, S, et al., & Duvauchelle, T (1997). First pharmacokinetic-pharmacodynamic study in humans with a selective 5-hydroxytryptamine4 receptor agonist. Journal of clinical pharmacology 37(3) 229–237. DOI:10.1002/j.1552-4604.1997.tb04785.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/9089425

Revisions


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