.Pharmacolibrary.Drugs.ATC.A.A07AA04_1

Information

name:Streptomycin_1
ATC code:A07AA04_1
route:intravenous
compartments:2
dosage:1000mg
volume of distribution:0.21L
clearance:1.2ml/min/kg
other parameters in model implementation

Streptomycin is an aminoglycoside antibiotic used to treat a variety of gram-negative and some gram-positive bacterial infections, notably tuberculosis. It is typically reserved for use in cases of tuberculosis and other specific infections due to resistance or intolerance to other agents. Streptomycin was historically very important but is now less commonly used due to the availability of newer antibiotics and risk of side effects.

Pharmacokinetics

Pharmacokinetic parameters in healthy adult subjects following single intravenous infusion.

References

  1. Zhu, M, et al., & Peloquin, CA (2001). Population pharmacokinetics of intravenous and intramuscular streptomycin in patients with tuberculosis. Pharmacotherapy 21(9) 1037–1045. DOI:10.1592/phco.21.13.1037.34625 PUBMED:https://pubmed.ncbi.nlm.nih.gov/11560193

  2. Sullins, AK, & Abdel-Rahman, SM (2013). Pharmacokinetics of antibacterial agents in the CSF of children and adolescents. Paediatric drugs 15(2) 93–117. DOI:10.1007/s40272-013-0017-5 PUBMED:https://pubmed.ncbi.nlm.nih.gov/23529866

Revisions


Generated at 2025-08-10T18:21:06Z by OpenModelicaOpenModelica 1.25.1 using GenerateDoc.mos