.Pharmacolibrary.Drugs.ATC.A.A08AB01 .Pharmacolibrary.Drugs.ATC.A.A08AB01| name: | Orlistat |
| ATC code: | A08AB01 | route: | oral |
| n-compartments | 1 |
Orlistat is a gastrointestinal lipase inhibitor used for the treatment of obesity. It works by inhibiting the absorption of dietary fats in the intestine. Orlistat is approved for both prescription and over-the-counter use in several countries for weight management in conjunction with a reduced-calorie diet.
Pharmacokinetic parameters are based on healthy adult volunteers. Orlistat, due to its minimal systemic absorption, exhibits very low plasma concentrations.
Zhi, J, et al., & Patel, IH (1995). Review of limited systemic absorption of orlistat, a lipase inhibitor, in healthy human volunteers. Journal of clinical pharmacology 35(11) 1103–1108. DOI:10.1002/j.1552-4604.1995.tb04034.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/8626884