.Pharmacolibrary.Drugs.ATC.A.A10AE04

Information

name:InsulinGlargine
ATC code:A10AE04
route:subcutaneous
n-compartments1

Insulin glargine is a long-acting insulin analog used to improve glycemic control in adults and children with diabetes mellitus. It is administered subcutaneously and provides a prolonged, relatively constant level of insulin activity. Insulin glargine is currently approved and widely used in clinical practice.

Pharmacokinetics

Pharmacokinetics in adult healthy volunteers and patients with diabetes (both type 1 and type 2); following subcutaneous administration.

References

  1. Faggionato, E, et al., & Man, CD (2021). Modeling Between-Subject Variability in Subcutaneous Absorption of a Long-Acting Insulin Glargine 100 U/mL by a Nonlinear Mixed Effects Approach. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 2021 4226–4229. DOI:10.1109/EMBC46164.2021.9629554 PUBMED:https://pubmed.ncbi.nlm.nih.gov/34892156

  2. Hurren, KM, & O'Neill, JL (2016). Pharmacodynamic and pharmacokinetic evaluation of insulin glargine U300 for the treatment of type 1 diabetes. Expert opinion on drug metabolism & toxicology 12(12) 1521–1526. DOI:10.1080/17425255.2016.1245722 PUBMED:https://pubmed.ncbi.nlm.nih.gov/27710135

  3. Rendell, M (2013). Insulin degludec: a long-acting modern insulin analogue with a predictable pharmacokinetic/pharmacodynamic profile. Drugs of today (Barcelona, Spain : 1998) 49(6) 387–397. DOI:10.1358/dot.2013.49.6.1976051 PUBMED:https://pubmed.ncbi.nlm.nih.gov/23807942

Revisions


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