.Pharmacolibrary.Drugs.ATC.A.A10BA02

Information

name:Metformin
ATC code:A10BA02
route:oral
n-compartments2

Metformin is an oral antihyperglycemic agent from the biguanide class, widely used for the treatment of type 2 diabetes mellitus. It is approved today and is considered the first-line pharmacological treatment for type 2 diabetes. Metformin lowers blood glucose primarily by inhibiting hepatic gluconeogenesis and improving insulin sensitivity.

Pharmacokinetics

Pharmacokinetic parameters based on healthy adult volunteers after a single oral dose.

References

  1. Graham, GG, et al., & Williams, KM (2011). Clinical pharmacokinetics of metformin. Clinical pharmacokinetics 50(2) 81–98. DOI:10.2165/11534750-000000000-00000 PUBMED:https://pubmed.ncbi.nlm.nih.gov/21241070

  2. Scheen, AJ (1996). Clinical pharmacokinetics of metformin. Clinical pharmacokinetics 30(5) 359–371. DOI:10.2165/00003088-199630050-00003 PUBMED:https://pubmed.ncbi.nlm.nih.gov/8743335

  3. Dhillon, S (2019). Dapagliflozin: A Review in Type 2 Diabetes. Drugs 79(10) 1135–1146. DOI:10.1007/s40265-019-01148-3 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31236801

Revisions

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