.Pharmacolibrary.Drugs.ATC.A.A10BB02 .Pharmacolibrary.Drugs.ATC.A.A10BB02| name: | Chlorpropamide | |
| ATC code: | A10BB02 | route: | oral |
| compartments: | 1 | |
| dosage: | 250 | mg |
| volume of distribution: | 0.21 | L |
| clearance: | 45 | ml/hr/kg |
| other parameters in model implementation | ||
Chlorpropamide is a first-generation sulfonylurea oral hypoglycemic agent used to manage type 2 diabetes mellitus. It acts by stimulating pancreatic insulin secretion. The medication is largely replaced by newer agents due to a higher risk of hypoglycemia but may still be used in certain cases.
Pharmacokinetic parameters in healthy adult subjects after a single oral dose.
Roe, DA (1985). Drug-food and drug-nutrient interactions. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 5(6) 115–135. PUBMED:https://pubmed.ncbi.nlm.nih.gov/3900336
Xu, H, et al., & McLachlan, AJ (2009). Influence of genetic polymorphisms on the pharmacokinetics and pharmaco-dynamics of sulfonylurea drugs. Current drug metabolism 10(6) 643–658. DOI:10.2174/138920009789375388 PUBMED:https://pubmed.ncbi.nlm.nih.gov/19799532