.Pharmacolibrary.Drugs.ATC.A.A10BD03 .Pharmacolibrary.Drugs.ATC.A.A10BD03| name: | MetforminAndRosiglitazone | |
| ATC code: | A10BD03 | route: | oral |
| compartments: | 1 | |
| dosage: | 500 | mg |
| volume of distribution: | 63 | L |
| clearance: | 505 | mL/min (metformin) |
| other parameters in model implementation | ||
Metformin and rosiglitazone is a fixed-dose combination oral medication used for the management of type 2 diabetes mellitus. Metformin is a biguanide that decreases hepatic glucose production and improves insulin sensitivity, while rosiglitazone is a thiazolidinedione that enhances insulin sensitivity in peripheral tissues. The combination is approved for use in several countries to improve glycemic control in adults with type 2 diabetes.
Population pharmacokinetics in healthy adults and patients with type 2 diabetes. Parameters are reported from studies involving oral administration of the fixed-dose combination tablet (metformin 500 mg/rosiglitazone 2 mg) in adults.