.Pharmacolibrary.Drugs.ATC.A.A10BD07 .Pharmacolibrary.Drugs.ATC.A.A10BD07| name: | MetforminAndSitagliptin | |
| ATC code: | A10BD07 | route: | oral |
| compartments: | 1 | |
| dosage: | 1000 | mg |
| volume of distribution: | 63 | L |
| clearance: | 505 | ml/min |
| other parameters in model implementation | ||
Metformin and sitagliptin is a fixed-dose combination antidiabetic medication used in the treatment of type 2 diabetes mellitus. Metformin is a biguanide antihyperglycemic agent that improves insulin sensitivity and reduces hepatic glucose production, while sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that increases incretin levels, thereby increasing insulin secretion and decreasing glucagon secretion. The combination is approved and widely used today for glycemic control in adults with type 2 diabetes.
Pharmacokinetic parameters for the combination tablet of metformin (1000 mg) and sitagliptin (100 mg) administered orally to healthy adult volunteers under fasting conditions, as reported in clinical studies.