.Pharmacolibrary.Drugs.ATC.A.A10BD18 .Pharmacolibrary.Drugs.ATC.A.A10BD18| name: | MetforminAndGemigliptin | |
| ATC code: | A10BD18 | route: | oral |
| compartments: | 1 | |
| dosage: | 1000 | mg |
| volume of distribution: | 90 | L |
| clearance: | 700 | mL/min |
| other parameters in model implementation | ||
Metformin and gemigliptin is a fixed-dose combination oral antidiabetic medication used in the management of type 2 diabetes mellitus. Metformin is a biguanide that decreases hepatic glucose production and increases insulin sensitivity, while gemigliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that increases incretin hormones, thereby improving glycemic control. This combination is approved and used clinically in several countries for patients who require both agents to achieve adequate glycemic control.
Pharmacokinetic parameters were estimated for healthy adult subjects based on published PK profiles for metformin and gemigliptin administered together; no study was identified reporting full compartmental model parameters for the fixed-dose combination under ATC A10BD18.