name: | CalciumChloride |
ATC code: | A12AA07 | route: | intravenous |
n-compartments | 1 |
Calcium chloride is an inorganic salt commonly used as a source of calcium in clinical medicine, notably for the treatment of hypocalcemia, hyperkalemia, and as a cardiac resuscitation adjunct for severe hypermagnesemia or calcium channel blocker toxicity. It is administered intravenously due to poor oral bioavailability and potential gastrointestinal irritation. Calcium chloride is approved for use in emergency medicine and critical care.
Estimated pharmacokinetics for healthy adults following a single intravenous bolus administration. No peer-reviewed population PK models found.
Ansari, JR, et al., & Shafer, SL (2025). Bioequivalence and Pharmacokinetics of Intravenous Calcium during Cesarean Delivery. Anesthesiology 142(1) 121–131. DOI:10.1097/ALN.0000000000005248 PUBMED:https://pubmed.ncbi.nlm.nih.gov/39361822
Bateman, RM, et al., & Prandi, E (2016). 36th International Symposium on Intensive Care and Emergency Medicine : Brussels, Belgium. 15-18 March 2016. Critical care (London, England) 20(Suppl 2) 94–None. DOI:10.1186/s13054-016-1208-6 PUBMED:https://pubmed.ncbi.nlm.nih.gov/27885969
Ansari, JR, et al., & Riley, E (2022). Calcium chloride for the prevention of uterine atony during cesarean delivery: A pilot randomized controlled trial and pharmacokinetic study. Journal of clinical anesthesia 80 110796–None. DOI:10.1016/j.jclinane.2022.110796 PUBMED:https://pubmed.ncbi.nlm.nih.gov/35447502