.Pharmacolibrary.Drugs.ATC.A.A12CD01 .Pharmacolibrary.Drugs.ATC.A.A12CD01| name: | SodiumFluoride |
| ATC code: | A12CD01 | route: | oral |
| n-compartments | 1 |
Sodium fluoride is an inorganic compound and source of fluoride ion. It is used primarily as a prophylactic agent against dental caries (tooth decay) and in water fluoridation, oral rinses, and supplements. It is approved and in use for caries prevention.
Pharmacokinetic parameters estimated for healthy adult humans after oral administration; no comprehensive original clinical PK study with full reporting found in literature.
Lin, YS, et al., & Milgrom, P (2018). Pharmacokinetics of Iodine and Fluoride following Application of an Anticaries Varnish in Adults. JDR clinical and translational research 3(3) 238–245. DOI:10.1177/2380084418771930 PUBMED:https://pubmed.ncbi.nlm.nih.gov/30938600
Ivanoff, CS, et al., & Garcia-Godoy, F (2013). Enhanced penetration of fluoride particles into bovine enamel by combining dielectrophoresis with AC electroosmosis. Electrophoresis 34(20-21) 2945–2955. DOI:10.1002/elps.201300206 PUBMED:https://pubmed.ncbi.nlm.nih.gov/23897721
Weinstein, P, et al., & Milgrom, P (2009). Randomized equivalence trial of intensive and semiannual applications of fluoride varnish in the primary dentition. Caries research 43(6) 484–490. DOI:10.1159/000264686 PUBMED:https://pubmed.ncbi.nlm.nih.gov/20016179