.Pharmacolibrary.Drugs.ATC.A.A16AB15 .Pharmacolibrary.Drugs.ATC.A.A16AB15| name: | VelmanaseAlfa | |
| ATC code: | A16AB15 | route: | intravenous |
| compartments: | 2 | |
| dosage: | 1 | mg |
| volume of distribution: | 73.3 | L |
| clearance: | 1.5 | mL/min/kg |
| other parameters in model implementation | ||
Velmanase alfa is a recombinant human alpha-mannosidase enzyme replacement therapy used for the treatment of alpha-mannosidosis, a rare lysosomal storage disorder. It is approved in the European Union for long-term enzyme replacement therapy in non-neurological manifestations of mild to moderate alpha-mannosidosis.
Pharmacokinetic parameters reported for adult and pediatric patients (both sexes) with alpha-mannosidosis following intravenous infusion of velmanase alfa (recombinant human alpha-mannosidase).