.Pharmacolibrary.Drugs.ATC.A.A16AX03 .Pharmacolibrary.Drugs.ATC.A.A16AX03| name: | SodiumPhenylbutyrate |
| ATC code: | A16AX03 | route: | oral |
| n-compartments | 1 |
Sodium phenylbutyrate is an aromatic fatty acid used as a nitrogen scavenger in the management of urea cycle disorders (UCDs). By promoting excretion of excess nitrogen, it is used to treat hyperammonemia due to enzyme deficiencies in the urea cycle. It is an FDA-approved therapy for this indication, and also investigated for possible adjunctive use in other rare metabolic diseases and disorders involving ammonia toxicity.
Pharmacokinetic parameters reported in healthy adult volunteers, both sexes, after a single oral dose under fasting conditions.
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