.Pharmacolibrary.Drugs.ATC.B.B01AD02 .Pharmacolibrary.Drugs.ATC.B.B01AD02| name: | Alteplase | |
| ATC code: | B01AD02 | route: | intravenous |
| compartments: | 2 | |
| dosage: | 100 | mg |
| volume of distribution: | 8.0 | L |
| clearance: | 550 | mL/min |
| other parameters in model implementation | ||
Alteplase is a recombinant tissue plasminogen activator (rt-PA) used for thrombolytic therapy. It is mainly indicated for the treatment of acute ischemic stroke, myocardial infarction, and pulmonary embolism and is approved for use in many countries today.
Pharmacokinetics reported in adult healthy volunteers and patients, typically following intravenous bolus or infusion administration.
Baek, JH, et al., & Bang, OY (2015). Predicting stroke outcome using clinical- versus imaging-based scoring system. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 24(3) 642–648. DOI:10.1016/j.jstrokecerebrovasdis.2014.10.009 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25576347