.Pharmacolibrary.Drugs.ATC.B.B01AX01 .Pharmacolibrary.Drugs.ATC.B.B01AX01| name: | Defibrotide | |
| ATC code: | B01AX01 | route: | intravenous |
| compartments: | 2 | |
| dosage: | 25 | mg |
| volume of distribution: | 7.2 | L |
| clearance: | 3.3 | L/h |
| other parameters in model implementation | ||
Defibrotide is an oligonucleotide mixture derived from porcine intestinal mucosa, used primarily for the treatment of severe hepatic veno-occlusive disease (VOD) in patients undergoing hematopoietic stem cell transplantation. It is an approved medication in many countries for this indication and has antithrombotic, anti-ischemic, and anti-inflammatory properties.
Pharmacokinetic parameters are reported for adult patients with severe hepatic veno-occlusive disease after intravenous administration.