.Pharmacolibrary.Drugs.ATC.B.B03XA02

Information

name:DarbepoetinAlfa
ATC code:B03XA02
route:intravenous
n-compartments2

Darbepoetin alfa is a synthetic analog of erythropoietin used to stimulate erythropoiesis. It is approved for the treatment of anemia associated with chronic kidney disease (CKD) and chemotherapy-induced anemia in cancer patients. It is longer-acting than recombinant human erythropoietin due to additional sialic acid groups.

Pharmacokinetics

Pharmacokinetic parameters in adults with chronic kidney disease after intravenous and subcutaneous administration. Subjects included both male and female patients, 18 to 75 years old, with stable renal function.

References

  1. An, G, et al., & Veng-Pedersen, P (2017). Population Pharmacokinetics of Darbepoetin in Infants Following Single Intravenous and Subcutaneous Dosing. Journal of pharmaceutical sciences 106(6) 1644–1649. DOI:10.1016/j.xphs.2017.02.001 PUBMED:https://pubmed.ncbi.nlm.nih.gov/28189627

  2. Roberts, JK, et al., & Sherwin, CM (2015). Population Pharmacokinetics of Darbepoetin Alfa in Conjunction with Hypothermia for the Treatment of Neonatal Hypoxic-Ischemic Encephalopathy. Clinical pharmacokinetics 54(12) 1237–1244. DOI:10.1007/s40262-015-0286-y PUBMED:https://pubmed.ncbi.nlm.nih.gov/25989868

  3. Agoram, B, et al., & Sullivan, JT (2007). Population pharmacokinetics of darbepoetin alfa in healthy subjects. British journal of clinical pharmacology 63(1) 41–52. DOI:10.1111/j.1365-2125.2006.02752.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/16939525

Revisions


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