.Pharmacolibrary.Drugs.ATC.B.B05CX04

Information

name:Mannitol
ATC code:B05CX04
route:intravenous
n-compartments1

Mannitol is an osmotic diuretic commonly used to reduce intracranial pressure and treat cerebral edema. It is also used to promote diuresis in renal failure and for excretion of toxic substances. Mannitol is approved for intravenous use in clinical practice.

Pharmacokinetics

Pharmacokinetics in healthy adults following intravenous administration.

References

  1. Deferm, N, et al., & Allegaert, K (2021). Glomerular Filtration Rate in Asphyxiated Neonates Under Therapeutic Whole-Body Hypothermia, Quantified by Mannitol Clearance. Clinical pharmacokinetics 60(7) 897–906. DOI:10.1007/s40262-021-00991-6 PUBMED:https://pubmed.ncbi.nlm.nih.gov/33611729

  2. Hahn, RG (2023). Isotonic saline causes greater volume overload than electrolyte-free irrigating fluids. Journal of basic and clinical physiology and pharmacology 34(6) 717–723. DOI:10.1515/jbcpp-2021-0032 PUBMED:https://pubmed.ncbi.nlm.nih.gov/34563101

  3. Kaneda, K, et al., & Todd, MM (2010). Pharmacokinetic characteristics of bolus-administered mannitol in patients undergoing elective craniotomy. Journal of clinical pharmacology 50(5) 536–543. DOI:10.1177/0091270009348973 PUBMED:https://pubmed.ncbi.nlm.nih.gov/20051588

Revisions


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