.Pharmacolibrary.Drugs.ATC.B.B05XA19

Information

Calcium gluconate is an intravenous medication used to treat hypocalcemia, hyperkalemia, hypermagnesemia, and for calcium channel blocker overdose. It is an approved drug with longstanding use in emergency and hospital settings.

Pharmacokinetics

Estimated pharmacokinetic parameters for adult individuals. No direct human PK studies with explicit parameter values are publicly available for calcium gluconate; data are estimated based on physicochemical similarity to calcium chloride and clinical context.

References

1. Ansari, JR, et al., & Shafer, SL (2025). Bioequivalence and Pharmacokinetics of Intravenous Calcium during Cesarean Delivery. Anesthesiology 142(1) 121–131. DOI:10.1097/ALN.0000000000005248 PUBMED:https://pubmed.ncbi.nlm.nih.gov/39361822

2. Bateman, RM, et al., & Prandi, E (2016). 36th International Symposium on Intensive Care and Emergency Medicine : Brussels, Belgium. 15-18 March 2016. Critical care (London, England) 20(Suppl 2) 94–None. DOI:10.1186/s13054-016-1208-6 PUBMED:https://pubmed.ncbi.nlm.nih.gov/27885969

3. Kaisbain, N, et al., & Kaisbain, V (2023). Verapamil-Induced Hypotension in End-Stage Renal Disease: The Role of Calcium Gluconate. Cureus 15(1) e33341–None. DOI:10.7759/cureus.33341 PUBMED:https://pubmed.ncbi.nlm.nih.gov/36741660

Revisions

• 06/2025 initial generated model