.Pharmacolibrary.Drugs.ATC.C.C01BD05

Information

Ibutilide is a class III antiarrhythmic agent that acts by prolonging the cardiac action potential and is primarily used for the rapid conversion of atrial fibrillation or atrial flutter of recent onset to normal sinus rhythm. It is approved for intravenous use in hospitals and acute care settings.

Pharmacokinetics

Pharmacokinetic parameters in healthy adult volunteers after intravenous administration.

References

1. Howard, PA (1999). Ibutilide: an antiarrhythmic agent for the treatment of atrial fibrillation or flutter. The Annals of pharmacotherapy 33(1) 38–47. DOI:10.1345/aph.18097 PUBMED:https://pubmed.ncbi.nlm.nih.gov/9972384

2. Li, Y, et al., & Hua, L (2007). Pharmacokinetic and pharmacodynamic properties of a single intravenous dose of ibutilide fumarate: a phase I, randomized, open-label, increasing-dose study in healthy Chinese men. Clinical therapeutics 29(9) 1957–1966. DOI:10.1016/j.clinthera.2007.09.010 PUBMED:https://pubmed.ncbi.nlm.nih.gov/18035195

Revisions

• 06/2025 initial generated model