.Pharmacolibrary.Drugs.ATC.C.C01CA03

Information

Norepinephrine (also known as noradrenaline) is a catecholamine with potent vasoconstrictor and inotropic effects. It is primarily used as a first-line vasopressor agent in the management of acute hypotension and shock, particularly septic shock, in critical care settings. It is approved and routinely used in clinical practice today.

Pharmacokinetics

Pharmacokinetics in healthy adult individuals after intravenous infusion.

References

1. Ashraf, MW, et al., & Saari, TI (2020). Population Modelling of Dexmedetomidine Pharmacokinetics and Haemodynamic Effects After Intravenous and Subcutaneous Administration. Clinical pharmacokinetics 59(11) 1467–1482. DOI:10.1007/s40262-020-00900-3 PUBMED:https://pubmed.ncbi.nlm.nih.gov/32462542

2. Li, Y, et al., & Colin, PJ (2024). Population Pharmacokinetic Modelling of Norepinephrine in Healthy Volunteers Prior to and During General Anesthesia. Clinical pharmacokinetics 63(11) 1597–1608. DOI:10.1007/s40262-024-01430-y PUBMED:https://pubmed.ncbi.nlm.nih.gov/39465453

3. Yoo, H, et al., & Jusko, WJ (2015). Mechanism-based population pharmacokinetic and pharmacodynamic modeling of intravenous and intranasal dexmedetomidine in healthy subjects. European journal of clinical pharmacology 71(10) 1197–1207. DOI:10.1007/s00228-015-1913-0 PUBMED:https://pubmed.ncbi.nlm.nih.gov/26233335

Revisions

• 06/2025 initial generated model