.Pharmacolibrary.Drugs.ATC.C.C01CA04

Information

Dopamine is an endogenous catecholamine neurotransmitter that acts as a nonselective agonist at dopamine, alpha, and beta adrenergic receptors. It is primarily used as a vasopressor and inotropic agent in the treatment of shock, particularly cardiogenic and septic shock, and sometimes in advanced heart failure. Dopamine is an approved drug used in clinical settings.

Pharmacokinetics

Pharmacokinetic parameters reported in healthy adult volunteers after intravenous infusion.

References

1. MacGregor, DA, et al., & Scuderi, PE (2000). Pharmacokinetics of dopamine in healthy male subjects. Anesthesiology 92(2) 338–346. DOI:10.1097/00000542-200002000-00013 PUBMED:https://pubmed.ncbi.nlm.nih.gov/10691218

2. Banner, W, et al., & Dean, JM (1991). Nonlinear dobutamine pharmacokinetics in a pediatric population. Critical care medicine 19(7) 871–873. DOI:10.1097/00003246-199107000-00008 PUBMED:https://pubmed.ncbi.nlm.nih.gov/2055074

3. Kwa, A, et al., & Jelliffe, RW (2008). A population pharmacokinetic model of epidural lidocaine in geriatric patients: effects of low-dose dopamine. Therapeutic drug monitoring 30(3) 379–389. DOI:10.1097/FTD.0b013e3181778fa3 PUBMED:https://pubmed.ncbi.nlm.nih.gov/18520611

Revisions

• 06/2025 initial generated model