name: | Dopamine_1 | |
ATC code: | C01CA04_1 | route: | intravenous |
compartments: | 2 | |
dosage: | 5 | mg |
volume of distribution: | 0.2 | L |
clearance: | 1.5 | L/min |
other parameters in model implementation |
Dopamine is an endogenous catecholamine neurotransmitter used as a vasopressor and inotropic agent in the treatment of shock and advanced heart failure. It acts on dopamine and adrenergic receptors and is approved for clinical use.
Estimated/typical pharmacokinetic parameters for intravenous infusion in adult patients, as referenced in clinical practice and secondary pharmacology textbooks.
MacGregor, DA, et al., & Scuderi, PE (2000). Pharmacokinetics of dopamine in healthy male subjects. Anesthesiology 92(2) 338–346. DOI:10.1097/00000542-200002000-00013 PUBMED:https://pubmed.ncbi.nlm.nih.gov/10691218
Banner, W, et al., & Dean, JM (1991). Nonlinear dobutamine pharmacokinetics in a pediatric population. Critical care medicine 19(7) 871–873. DOI:10.1097/00003246-199107000-00008 PUBMED:https://pubmed.ncbi.nlm.nih.gov/2055074
Kwa, A, et al., & Jelliffe, RW (2008). A population pharmacokinetic model of epidural lidocaine in geriatric patients: effects of low-dose dopamine. Therapeutic drug monitoring 30(3) 379–389. DOI:10.1097/FTD.0b013e3181778fa3 PUBMED:https://pubmed.ncbi.nlm.nih.gov/18520611