.Pharmacolibrary.Drugs.ATC.C.C01CA06_1

Information

name:Phenylephrine_1
ATC code:C01CA06_1
route:oral
n-compartments1

Phenylephrine is a selective alpha-1 adrenergic receptor agonist used primarily as a decongestant, to increase blood pressure in hypotensive states such as shock, and as a mydriatic agent for ophthalmic procedures. It is approved for use via various routes including oral, intravenous, and topical administration. Injectable phenylephrine is used in hospital settings for acute hypotension.

Pharmacokinetics

Oral administration, healthy fasting adults, single dose. Both males and females (age 18–55 years)

References

  1. Atkinson, HC, et al., & Anderson, BJ (2015). Potential cardiovascular adverse events when phenylephrine is combined with paracetamol: simulation and narrative review. European journal of clinical pharmacology 71(8) 931–938. DOI:10.1007/s00228-015-1876-1 PUBMED:https://pubmed.ncbi.nlm.nih.gov/26022219

  2. Atkinson, HC, et al., & Anderson, BJ (2015). Increased bioavailability of phenylephrine by co-administration of acetaminophen: results of four open-label, crossover pharmacokinetic trials in healthy volunteers. European journal of clinical pharmacology 71(2) 151–158. DOI:10.1007/s00228-014-1788-5 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25475358

  3. Vincent, J, et al., & Reid, JL (1986). Racial differences in drug responses--a comparative study of trimazosin and alpha 1-adrenoceptor responses in normotensive Caucasians and West Africans. British journal of clinical pharmacology 21(4) 401–408. DOI:10.1111/j.1365-2125.1986.tb05214.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/3011048

Revisions


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