name: | Droxidopa |
ATC code: | C01CA27 | route: | oral |
n-compartments | 1 |
Droxidopa is a synthetic amino acid precursor of norepinephrine. It is used as a prodrug to increase norepinephrine concentrations, primarily for the treatment of neurogenic orthostatic hypotension in patients with Parkinson’s disease, multiple system atrophy, pure autonomic failure, dopamine beta-hydroxylase deficiency, and non-diabetic autonomic neuropathy. It is currently approved for use in several countries, including the United States.
Pharmacokinetic parameters estimated for oral droxidopa use in adults with neurogenic orthostatic hypotension; general adult population with normal hepatic and renal function.