.Pharmacolibrary.Drugs.ATC.C.C01EB10 .Pharmacolibrary.Drugs.ATC.C.C01EB10| name: | Adenosine |
| ATC code: | C01EB10 | route: | intravenous |
| n-compartments | 1 |
Adenosine is an endogenous purine nucleoside approved for the rapid conversion of paroxysmal supraventricular tachycardia (PSVT) to normal sinus rhythm. It acts on adenosine receptors to inhibit conduction through the atrioventricular node and is used primarily in acute cardiac care settings. Adenosine is approved and widely used today as an intravenous antiarrhythmic agent.
Pharmacokinetic model reported in healthy adult subjects; most data from intravenous administration due to extremely low oral bioavailability.
Motovska, Z, et al., & Group, DS (2024). Cangrelor versus crushed ticagrelor in patients with acute myocardial infarction and cardiogenic shock: rationale and design of the randomised, double-blind DAPT-SHOCK-AMI trial. EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology 20(20) e1309–e1318. DOI:10.4244/EIJ-D-24-00203 PUBMED:https://pubmed.ncbi.nlm.nih.gov/39432252
Bateman, RM, et al., & Prandi, E (2016). 36th International Symposium on Intensive Care and Emergency Medicine : Brussels, Belgium. 15-18 March 2016. Critical care (London, England) 20(Suppl 2) 94–None. DOI:10.1186/s13054-016-1208-6 PUBMED:https://pubmed.ncbi.nlm.nih.gov/27885969
Ahmed, A, et al., & Rojo, P (2024). Remdesivir for COVID-19 in Hospitalized Children: A Phase 2/3 Study. Pediatrics 153(3) –. DOI:10.1542/peds.2023-063775 PUBMED:https://pubmed.ncbi.nlm.nih.gov/38332740