.Pharmacolibrary.Drugs.ATC.C.C02DD01

Information

Nitroprusside, also known as sodium nitroprusside, is a fast-acting vasodilator primarily used in emergency settings to manage hypertensive crises and acute heart failure. It acts by releasing nitric oxide, which relaxes vascular smooth muscle, leading to reduced blood pressure. It is still in clinical use, particularly for short-term intravenous management of severe hypertension.

Pharmacokinetics

Pharmacokinetic parameters determined from adult patients following intravenous infusion (hypertensive crises). Typically healthy or acute cardiac patients, both sexes, average age 35-60.

References

1. Thomas, C, et al., & Moffett, BS (2009). Sodium-nitroprusside-induced cyanide toxicity in pediatric patients. Expert opinion on drug safety 8(5) 599–602. DOI:10.1517/14740330903081717 PUBMED:https://pubmed.ncbi.nlm.nih.gov/19645589

2. Kamp, J, et al., & Olofsen, E (2020). Pharmacokinetics of ketamine and its major metabolites norketamine, hydroxynorketamine, and dehydronorketamine: a model-based analysis. British journal of anaesthesia 125(5) 750–761. DOI:10.1016/j.bja.2020.06.067 PUBMED:https://pubmed.ncbi.nlm.nih.gov/32838982

3. Noviawaty, I, et al., & Qureshi, AI (2008). Drug evaluation of clevidipine for acute hypertension. Expert opinion on pharmacotherapy 9(14) 2519–2529. DOI:10.1517/14656566.9.14.2519 PUBMED:https://pubmed.ncbi.nlm.nih.gov/18778189

Revisions

• 06/2025 initial generated model