.Pharmacolibrary.Drugs.ATC.C.C02KX03 .Pharmacolibrary.Drugs.ATC.C.C02KX03| name: | Sitaxentan | |
| ATC code: | C02KX03 | route: | oral |
| compartments: | 2 | |
| dosage: | 100 | mg |
| volume of distribution: | 25 | L |
| clearance: | 4.1 | L/h |
| other parameters in model implementation | ||
Sitaxentan is an endothelin receptor antagonist developed for the treatment of pulmonary arterial hypertension (PAH). It selectively blocks the endothelin-A receptor. Sitaxentan was withdrawn globally due to liver toxicity concerns and is not currently approved or in clinical use.
Population pharmacokinetics reported for adult patients with pulmonary arterial hypertension after oral dosing.