.Pharmacolibrary.Drugs.ATC.C.C02LG03

Information

name:PicodralazineAndDiuretics
ATC code:C02LG03
route:oral
n-compartments1

Picodralazine is a vasodilator antihypertensive agent, usually combined with diuretics for the management of high blood pressure. It is classified under the ATC code C02LG03. The combination is used to lower blood pressure in patients where monotherapy is insufficient. Picodralazine is not widely used today and is not approved in most modern formularies.

Pharmacokinetics

No published pharmacokinetic parameters specific to picodralazine and diuretics combination have been identified in the literature for any subgroup of patients. Parameters below are estimated based on typical pharmacokinetics for similar antihypertensive vasodilators administered orally in adults.

References

  1. Wang, EB, et al., & Dickinson, GL (2017). Population Pharmacokinetics of LY2623091 in Patients With Hypertension and Chronic Kidney Disease. Journal of clinical pharmacology 57(6) 739–746. DOI:10.1002/jcph.865 PUBMED:https://pubmed.ncbi.nlm.nih.gov/28144958

  2. Pelligand, L, et al., & Jacobs, M (2020). Population Pharmacokinetics and Pharmacodynamics Modeling of Torasemide and Furosemide After Oral Repeated Administration in Healthy Dogs. Frontiers in veterinary science 7 151–None. DOI:10.3389/fvets.2020.00151 PUBMED:https://pubmed.ncbi.nlm.nih.gov/32411731

  3. Tsai, MC, et al., & Vakilynejad, M (2016). Population Pharmacokinetics and Exposure-Response of a Fixed-Dose Combination of Azilsartan Medoxomil and Chlorthalidone in Patients With Stage 2 Hypertension. Journal of clinical pharmacology 56(8) 988–998. DOI:10.1002/jcph.684 PUBMED:https://pubmed.ncbi.nlm.nih.gov/26632101

Revisions


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