.Pharmacolibrary.Drugs.ATC.C.C03BB04 .Pharmacolibrary.Drugs.ATC.C.C03BB04| name: | ChlortalidoneAndPotassium |
| ATC code: | C03BB04 | route: | oral |
| n-compartments | 1 |
Chlortalidone and potassium is a combination medication used in the management of hypertension and edema. Chlortalidone is a thiazide-like diuretic that reduces blood pressure and fluid retention by inhibiting sodium reabsorption in the distal tubules of the kidney, whereas potassium supplementation helps prevent hypokalemia, a common side effect of chlortalidone. The combination is approved and used in clinical practice for cardiovascular risk reduction and hypertension control.
No pharmacokinetic studies or published models specific for the fixed combination of chlortalidone and potassium were identified. The following are estimates based on single-agent chlortalidone PK data in healthy adults (general population); potassium PK modeling is not relevant, as it is a supplement and not modeled in the same manner as xenobiotic drugs.