.Pharmacolibrary.Drugs.ATC.C.C03CA01_1 .Pharmacolibrary.Drugs.ATC.C.C03CA01_1| name: | Furosemide_1 | |
| ATC code: | C03CA01_1 | route: | intravenous |
| compartments: | 2 | |
| dosage: | 40 | mg |
| volume of distribution: | 7 | L |
| clearance: | 7.5 | L/h |
| other parameters in model implementation | ||
Furosemide is a potent loop diuretic used for edema and hypertension, approved and widely prescribed.
Pharmacokinetic parameters reported for healthy adult subjects after a single intravenous bolus dose.
Van Wart, SA, et al., & Mager, DE (2014). Population-based meta-analysis of furosemide pharmacokinetics. Biopharmaceutics & drug disposition 35(2) 119–133. DOI:10.1002/bdd.1874 PUBMED:https://pubmed.ncbi.nlm.nih.gov/24151207
Hammarlund-Udenaes, M, & Benet, LZ (1989). Furosemide pharmacokinetics and pharmacodynamics in health and disease--an update. Journal of pharmacokinetics and biopharmaceutics 17(1) 1–46. DOI:10.1007/BF01059086 PUBMED:https://pubmed.ncbi.nlm.nih.gov/2654356
Chay, S, et al., & Tobin, T (1983). The pharmacology of furosemide in the horse. V. Pharmacokinetics and blood levels of furosemide after intravenous administration. Drug metabolism and disposition: the biological fate of chemicals 11(3) 226–231. PUBMED:https://pubmed.ncbi.nlm.nih.gov/6135581