.Pharmacolibrary.Drugs.ATC.C.C05AE02

Information

name:IsosorbideDinitrate
ATC code:C05AE02
route:oral
compartments:2
dosage:20mg
volume of distribution:2.4L
clearance:3.4L/min
other parameters in model implementation

Isosorbide dinitrate is an organic nitrate vasodilator used for the prevention and treatment of angina pectoris due to coronary artery disease. It acts by relaxing vascular smooth muscle via nitric oxide release, and has been used as an approved antianginal agent for decades.

Pharmacokinetics

Pharmacokinetic parameters reported for healthy adult volunteers after single oral dose administration.

References

  1. Leier, CV (1985). Nitrate tolerance. American heart journal 110(1 Pt 2) 224–232. DOI:10.1016/0002-8703(85)90491-0 PUBMED:https://pubmed.ncbi.nlm.nih.gov/3925742

  2. Liu, Z, et al., & Guo, R (2015). CGRP mediate the isosorbide-5-mononitrate cardiovascular response in healthy Chinese male volunteers through a XOR-independent pathway. International journal of clinical pharmacology and therapeutics 53(4) 325–334. DOI:10.5414/CP202178 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25740261

Revisions


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