.Pharmacolibrary.Drugs.ATC.C.C07FX05 .Pharmacolibrary.Drugs.ATC.C.C07FX05| name: | MetoprololAndIvabradine | |
| ATC code: | C07FX05 | route: | oral |
| compartments: | 1 | |
| dosage: | 50 | mg |
| volume of distribution: | 200 | L |
| clearance: | 60 | L/h |
| other parameters in model implementation | ||
Fixed-dose combination containing metoprolol, a beta-1 selective adrenergic blocker, and ivabradine, a selective If current inhibitor. The combination is intended for use in adults with chronic heart failure and/or angina pectoris to reduce heart rate and control symptoms. This drug combination is approved and used in some countries for these indications.
Pharmacokinetic parameter estimates are based on published data for the individual drugs in healthy adult subjects; no published population PK model exists for the fixed-dose combination. Reported values are typical for oral administration in adults.