name: | Amlodipine | |
ATC code: | C08CA01 | route: | oral |
compartments: | 2 | |
dosage: | 5 | mg |
volume of distribution: | 21 | L |
clearance: | 7.5 | L/h |
other parameters in model implementation |
Amlodipine is a long-acting dihydropyridine calcium channel blocker used primarily for the treatment of hypertension and angina pectoris. It is orally administered and is widely approved and used as first-line therapy for blood pressure control.
Pharmacokinetic parameters reported in healthy adult volunteers after a single oral 5 mg dose.
van der Vossen, AC, et al., & Hanff, LM (2020). Use of amlodipine oral solution for the treatment of hypertension in children. International journal of clinical pharmacy 42(3) 848–852. DOI:10.1007/s11096-020-01000-9 PUBMED:https://pubmed.ncbi.nlm.nih.gov/32378123
Ngo, L, et al., & Lee, YB (2018). Effects of hydrochlorothiazide and amlodipine on single oral dose pharmacokinetics of valsartan in healthy Korean subjects: Population model-based approach. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 118 154–164. DOI:10.1016/j.ejps.2018.03.031 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29604332
Abernethy, DR (1989). The pharmacokinetic profile of amlodipine. American heart journal 118(5 Pt 2) 1100–1103. DOI:10.1016/0002-8703(89)90834-x PUBMED:https://pubmed.ncbi.nlm.nih.gov/2530866