.Pharmacolibrary.Drugs.ATC.C.C08CA02

Information

name:Felodipine
ATC code:C08CA02
route:oral
n-compartments2

Felodipine is a dihydropyridine calcium channel blocker used primarily for the treatment of hypertension and angina pectoris. It works by relaxing vascular smooth muscle and reducing peripheral resistance. Felodipine is an approved and widely used antihypertensive agent.

Pharmacokinetics

Pharmacokinetic parameters reported in healthy adult volunteers after single oral administration.

References

  1. Blychert, E, et al., & Hedner, T (1991). A population study of the pharmacokinetics of felodipine. British journal of clinical pharmacology 31(1) 15–24. DOI:10.1111/j.1365-2125.1991.tb03852.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/2015166

  2. Wade, JR, & Sambol, NC (1995). Felodipine population dose-response and concentration-response relationships in patients with essential hypertension. Clinical pharmacology and therapeutics 57(5) 569–581. DOI:10.1016/0009-9236(95)90042-X PUBMED:https://pubmed.ncbi.nlm.nih.gov/7768080

  3. Xiang, Q, et al., & Cui, YM (2017). The influence of CYP3A5*3 and BCRPC421A genetic polymorphisms on the pharmacokinetics of felodipine in healthy Chinese volunteers. Journal of clinical pharmacy and therapeutics 42(3) 345–349. DOI:10.1111/jcpt.12505 PUBMED:https://pubmed.ncbi.nlm.nih.gov/28244604

Revisions


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