.Pharmacolibrary.Drugs.ATC.C.C08CA04_1 .Pharmacolibrary.Drugs.ATC.C.C08CA04_1| name: | Nicardipine_1 |
| ATC code: | C08CA04_1 | route: | intravenous |
| n-compartments | 2 |
Nicardipine is a dihydropyridine calcium channel blocker used in the management of hypertension and angina pectoris. It works primarily by relaxing vascular smooth muscle, thus dilating blood vessels to reduce blood pressure. Nicardipine is approved and widely used for acute hypertension, including hypertensive emergencies and for short-term management of high blood pressure.
Critically ill patients, continuous intravenous infusion.
Modi, NB, et al., & Dow, RJ (1993). Application of a system analysis approach to population pharmacokinetics and pharmacodynamics of nicardipine hydrochloride in healthy males. Journal of pharmaceutical sciences 82(7) 705–713. DOI:10.1002/jps.2600820707 PUBMED:https://pubmed.ncbi.nlm.nih.gov/8360844
Strauser, LM, et al., & Tobias, JD (2000). Initial experience with isradipine for the treatment of hypertension in children. Southern medical journal 93(3) 287–293. PUBMED:https://pubmed.ncbi.nlm.nih.gov/10728516
Noviawaty, I, et al., & Qureshi, AI (2008). Drug evaluation of clevidipine for acute hypertension. Expert opinion on pharmacotherapy 9(14) 2519–2529. DOI:10.1517/14656566.9.14.2519 PUBMED:https://pubmed.ncbi.nlm.nih.gov/18778189